What Does lax Mean
From the Latin laxus , lax is an adjective that refers to something relaxed, free or that does not have the tension that, by nature, it should have . The term can be used in reference to something physical or symbolic.
For example: "I like looser fabrics, which do not cling to the body so much" , "He was always a man of lax beliefs, capable of contradicting himself with great naturalness" , "A loose tablecloth that does not conform to the table is the best decorative option for the banquet ” , “ You cannot be lax in complying with the rules ” .
The type of tissue in the body that has a low percentage of fibers and whose origin is in the mesechymal tissue is known as loose connective tissue . Loose connective tissue can be divided into mucosal connective tissue or reticular connective tissue , among other subtypes.
In a symbolic sense, the lax is associated with vagueness , impression, or the indefinite . If a person affirms that he has a "loose relationship" with his romantic partner, he will be indicating that the degree of commitment is not very strong. Similarly, a president who provides "lax support" to a minister will be giving him an endorsement that may be seen as weak or that is open to misunderstandings and misrepresentations.
The loose skin , moreover, is a disease rarely involves the degeneration of the elastic fibers of the skin . It is caused by a defect in the lysyl oxidase enzyme that causes the skin to become loose and appear to hang from the body .
Most cases of loose skin are inherited in an autosomal recessive, dominant, or X-linked recessive form, although there are reports of acquired cases. Given the histological abnormalities in the structure or amount of elastin that occur in almost all cases of skin laxity, research studies have focused on genetic mutations that lead to alterations in the processing of elastin in the extracellular matrix or in the structure.
Autosomal dominant lax cutis (ADCL)
The ADCL symptoms may appear at any point in the development of a person between birth and the beginning of adulthood. In some cases, only the symptom of lax skin is seen. However, certain families see defects in the eyes and nose, as well as lung problems (pulmonary emphysema) and vascular (aortic aneurysms). It is advisable to carry out pulmonary function tests and an echocardiography to prevent the aforementioned disorders, since they can put the patient's life at risk.
Autosomal recessive lax cutis (ARCL)
ARCL is found in various subtypes, depending on the symptoms of each case and the gene causing the disease; basically, three types can be recognized, and the first two are also divided into more than one subtype. Let's see the main characteristics of some of them:
ARCL1A
* loose skin, lung problems such as emphysema (during the first years of life) and hernias;
* the age at which these symptoms appear varies greatly, even within a family;
* is due to mutations in the FBLN5 gene.
ARCL2A
* wrinkled skin all over the body (age generally makes this better);
* congenital dislocation of the hip, myopia, hernias and elongated anterior fontanelle;
* Many cases have a significant delay in psychomotor development and crises of epilepsy;
* is caused by mutations in the ATP6V0A2 gene.
ARCL3
* growth and mental retardation (of varying intensity);
* cataracts, lax joints;
* appearance of excessive aging;
* The disorders pulmonary and cardiovascular are not common.