What are the causes of an unexplained rash?

Some causes of an unexplained skin rash are an allergic reaction, abrasive clothing, and chronic fatigue syndrome. An allergic reaction is an especially common cause of unexplained rashes, but the patient often never finds out what they came in contact with or what caused the reaction. Chronic fatigue syndrome is a rarer cause, but researchers aren't sure how rare it is due to poor understanding of the condition and how many people worldwide go undiagnosed. In some cases, the rash is caused by an immune response due to an autoimmune disorder.

An unexplained skin rash is often caused by an allergic reaction to a foreign or unusual substance. Sometimes allergic reactions are mild and only cause symptoms like rashes and itching, but other times they can be more dangerous. One thing that often causes an unusual allergic reaction is a new laundry detergent, so it's often a good idea to consider new substances that have been introduced into an environment when trying to eliminate the cause of an allergic reaction. Insect bites, food, and other substances can also cause an allergic reaction and unexplained rash.

Sometimes an unexplained rash is caused by something as simple as abrasive clothing or friction. New clothes are more suspicious than old clothes when people encounter an unexplained skin rash, possibly due to abrasive material. Other times, the rash is caused by friction, either friction against a person's own skin, clothing, or something else that irritates the skin and eventually causes it to break out as a rash.

Chronic fatigue syndrome is a condition in which the patient has unexplained fatigue for at least six months. There is no way to diagnose a patient with chronic fatigue other than to rule out all other potential causes of fatigue and to consider any other symptoms. Some people with chronic fatigue syndrome develop an unexplained skin rash, while others suffer from headaches and a low-grade afternoon fever. As the causes of unexplained skin rashes disappear, it is believed that this is quite rare, but the vast majority of people with chronic fatigue syndrome go undiagnosed.

Autoimmune progesterone dermatitis (APD) is a condition that causes women to develop skin rashes due to their menstrual cycle. This health problem is rare and not fully understood, but researchers believe the rash is a response to hormonal changes in a woman's body. Women with APD develop a skin rash before their period, which goes away within a few days of menstruation. Those who are undergoing hormone therapy, such as taking birth control pills, may be more likely to experience APD.

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